A new translation of Pierre Bayle's first great work, which undermines the influence of "superstition" in political life and laid the groundwork for the separation of church and state.

This paper is about two kinds of mental content and how they are related. We are going to call them representation and indication. We will begin with a rough characterization of each. The differences, and why they matter, will, hopefully, become clearer as the paper proceeds.

Prosocial compensation is a corporate social responsibility practice that involves donating money to a charitable cause on behalf of customers as a means to compensate them for their loss after a service failure. In order to determine the effectiveness of PC, we carried out three experiments while also comparing its effectiveness within private and public settings. Experiment 1 focused on the signaling effects of communicating the promise to offer PC to potential customers in the event of service failure. Results show (...) that, in both private and public settings, PC has positive effects on corporate image, credibility, and word-of-mouth intent. More significantly, PC improved one’s CSR image, whereas more tangible compensation, such as a gift voucher, did not. Experiments 2A and 2B focused on the effects of offering PC after a service failure on perceptions of justice. Results show that PC contributes to perceived distributive justice, procedural justice, and post-recovery satisfaction in both private and public settings. Our study showed that PC could be a relevant new CSR practice for organizations wanting to enhance theirs CSR image while contributing to fulfilling their ethical and philanthropic CSR responsibilities. We discuss the implications of our findings and offer several avenues for follow-up research on this initial study on PC. (shrink)

BackgroundIn this article, we address questions regarding how people consider what they do or do not consent to and the reasons why. This article presents the findings of a citizen forum study conducted by the University of Geneva in partnership with the Geneva University Hospitals to explore the opinions and concerns of members of the public regarding predictive oncology, genetic sequencing, and cancer. MethodsThis paper presents the results of a citizen forum that included 73 participants. A research tool titled "the (...) mechanics of consent" was designed for this study. This tool is a table encouraging participants to reflect on social and research actors, types of data, and desired levels of control while sharing different types of data with different actors. Participants’ discussion that led to the completion of each table were audio-recorded, transcribed, and analyzed using thematic analysis.ResultsThe results are a compilation of responses from the mechanics of consent tool divided into two sections; the first presents quantitative results of collective responses regarding attitudes to consent to donate their data. The second section present qualitative findings emerged from the discussion amongst participants.DiscussionChoice and control of personal data is crucial for the public to be able to decide who and how to trust. Key information to be disclosed to potential research participants shall include information about potential risks and benefits; who will be accessing and using their data; as well as assurances that their choice will be respected. Furthermore, researchers ought to make sure they are trustworthy, by acting in a competent, reliable, and honest manner. Governance systems ought to be better equipped to address ethical issues raise by the growing presence of non-traditional research actors, consent of exchanges of data via digital devices and online activity such as social media and fairness of data trading. Finally, informed consent is one of the various elements that contribute to conducting ethical research. More needs to be done to strengthen governance and ensure adequate protection of research participants, particularly to address issues related to predictive health analytics. (shrink)

The mammalian pineal gland contains two types of N‐acetyltransferases which act on aromatic amines. One type preferentially acetylates arylamines such as phenetidine and aniline, whereas the other preferentially acetylates arylalkylamines such as tryptamine and phenylethylamine. The two enzymes can be distinguished by (1) molecular size, (2) regulation, and (3) inactivation characteristics. Arylalkylamine N‐acetyltransferase is involved in the regulation of melatonin synthesis in the pineal gland. A specific function of pineal arylamine N‐acetyltransferase has not been established; it may function as a (...) nonspecific detoxification mechanism. (shrink)

Advances in artificial intelligence, as well as its increased presence in everyday life, have brought the emergence of many new phenomena, including an intriguing appearance of what seems to be a variant of body dysmorphic disorder, coined “Snapchat dysmorphia”. Body dysmorphic disorder is a DSM-5 psychiatric disorder defined as a preoccupation with one or more perceived defects or flaws in physical appearance that are not observable or appear slight to others. Snapchat dysmorphia is fueled by automated selfie filters that reflect (...) unrealistic sociocultural standard. In this paper, we discuss how body dysmorphic disorder and related body image distortions could arise, using the conceptual resources provided by the active inference framework. We suggest that these disorders involve dysfunctional self-modelling which entails maladaptive internalization of sociocultural preferences during adolescent identity formation. Identity formation is hereby described as cycles of interpersonal active inference that arbitrate between identity exploration and commitment. We propose that impaired self-modelling is unable to reduce interpersonal uncertainty during identity exploration, which, over time, degenerates into uncontrollable epistemic habits that isolate the body image from corrective sensory evidence. In light of these insights, we subsequently explore some of the consequences of image-centered social media platforms on the identity formation process. We conclude that heightened interpersonal uncertainty in this novel context could precipitate the onset of body dysmorphic disorder and related body image distortions, particularly when selfie filters are involved. (shrink)

Pierre Soulages : régulièrement j’élimine des toiles, inabouties ou qui ont “tourné mal ”, banales, sans rien qui m’excite et qui sont d’ailleurs des sortes d’aventures avortées… Alors qu’à un moment, il y avait quelque chose qui était apparu, qui me paraissait intéressant à pousser, à intensifier, et puis ça s’est détourné, ça s’est terminé par quelque chose de morne, pas vraiment inachevé parce que l’inachevé c’est par rapport à un modèle parfait ou… qui n’est pas du tout ce (...) que je poursuiv... (shrink)

It has been commonplace in epistemology since its inception to idealize away from computational resource constraints, i.e., from the constraints of time and memory. One thought is that a kind of ideal rationality can be specified that ignores the constraints imposed by limited time and memory, and that actual cognitive performance can be seen as an interaction between the norms of ideal rationality and the practicalities of time and memory limitations. But a cornerstone of naturalistic epistemology is that normative assessment (...) is constrained by capacities: you cannot require someone to do something they cannot or, as it is usually put, ought implies can. This much we take to be uncontroversial. We argue that differences in architectures, goals and resources imply substantial differences in capacity, and that some of these differences are ineliminable. It follows that some differences in goals and architectural and computational resources matter at the normative level: they constrain what principles of normative epistemology can be used to describe and prescribe their behavior. As a result, we can expect there to be important epistemic differences between the way brains, individuals, and science work. (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM – whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part 1 of this article took up the first two questions. Part 2 took up the second two questions. Part 3 now deals with Questions 5 & 6. Question 5 confronts the issue of utility, whether the manual design of DSM-III and IV favors clinicians or researchers, and what that means for DSM-5. Our final question, Question 6, takes up a concluding issue, whether the acknowledged problems with the earlier DSMs warrants a significant overhaul of DSM-5 and future manuals. As in Parts 1 & 2 of this article, the general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

In the conclusion to this multi-part article I first review the discussions carried out around the six essential questions in psychiatric diagnosis – the position taken by Allen Frances on each question, the commentaries on the respective question along with Frances’ responses to the commentaries, and my own view of the multiple discussions. In this review I emphasize that the core question is the first – what is the nature of psychiatric illness – and that in some manner all further (...) questions follow from the first. Following this review I attempt to move the discussion forward, addressing the first question from the perspectives of natural kind analysis and complexity analysis. This reflection leads toward a view of psychiatric disorders – and future nosologies – as far more complex and uncertain than we have imagined. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Un dialogue est un logos (discours, propos, argument) qui va d'un interlocuteur a un autre. Cet echange d'idees, s'il veut etre fructueux, s'appuie sur un principe tres simple: comme le dialogue n'est pas un monologue, on dialogue avec quelqu'un; et on dialogue sur quelque chose. C'est le cas des travaux qui composent ce volume. L'interlocuteur privilegie est Pierre Aubenque. Ses travaux, son activite en tant qu'enseignant, ses prises de position sur des sujets tres divers ont suscite, de la part (...) de ses disciples, collegues et amis, une veritable envie de dialoguer avec lui, un desir de suivre son exemple (car Pierre Aubenque a toujours dialogue avec les Anciens, notamment avec Aristote). Les auteurs de ces reflexions ont ainsi voulu demontrer que le dialogue instaure pendant plus de vingt ans par le Directeur du centre Leon Robin (Universite de Paris IV), reste toujours ouvert. (shrink)

Pierre Mathieu L’analyse des publications et des textes de conférences du cistercien québécois Yves Girard permet de dégager un thème majeur de sa théologie spirituelle : le désir de l’être, interprété par lui comme un désir de rencontre avec Dieu. C’est un désir inconscient, inscrit dans la structure de l’être par le Créateur qui désire être en relation avec ses créatures. Selon l’auteur, nous possédons déjà ce que nous désirons, une richesse intérieure à laquelle le silence nous donne accès.

In this article, we develop tame topology over dp-minimal structures equipped with definable uniformities satisfying certain assumptions. Our assumptions are enough to ensure that definable sets are tame: there is a good notion of dimension on definable sets, definable functions are almost everywhere continuous, and definable sets are finite unions of graphs of definable continuous “multivalued functions.” This generalizes known statements about weakly o-minimal, C-minimal, and P-minimal theories.

Comment nous orienter dans le monde? C'est la philosophie politique qui peut le mieux nous y aider, répond Pierre Marient. Son livre propose un tableau raisonné du monde actuel. Il est, par là même, nécessairement aussi une réflexion sur le siècle écoulé, sur les guerres et les totalitarismes qui en ont occupé une si grande part. L'auteur s'efforce de saisir les articulations selon lesquelles notre monde s'ordonne et se meut. Il considère d'abord notre régime - la démocratie; puis notre (...) forme politique - la nation. Il réfléchit sur les rapports que l'une entretient avec l'autre et sur la crise qui les menace : au seuil du nouveau siècle, la démocratie tend à se détacher non seulement du cadre politique national accoutumé, mais même de toute forme politique reconnaissable. Les cœurs sont émus et les esprits obnubilés par la perspective prochaine d'une démocratie pure, délivrée de la vieille politique, et qui régnerait sans partage selon les règles du droit et les maximes de la morale. Telle est la " grande illusion " de notre temps. Cette " grande illusion ", selon Pierre Marient, est de voir dans la politique l'obstacle qui nous empêche d'accéder à la vraie vie. C'est au contraire l'ordre politique qui est le véritable ordre humain. (shrink)

The notion of “intentionality” is much invoked in various foundational theories of meaning, being very often equated with “meaning”, “content” and “reference”. In this paper, I propose and develop a basic distinction between two concepts and, more fundamentally, properties of intentionality: intentionality-T and intentionality-C. Representationalism is then defined as the position according to which intentionality-T can be reduced to intentionality-C, in the form of representational states. Nonrepresentationalism is rejecting this reduction, and argues that intentionality-T is more fundamental than intentionality-C. Non-representationalism (...) allows for a new layered view of the relations between cognitive intentionality and linguistic intentionality; this view is presented at the end of the paper. (shrink)

L’article part du contemporain et de ce qui en affecte le religieux, un effondrement des médiations sociales et la montée de religiosités privées vivant d’un rapport direct à la vérité. Il reprend ensuite certains des motifs en cause, décalant les oppositions reçues. Ainsi sur les médiations, à repenser en lien à ce que sont tant le religieux que le social, sur l’extériorité, à repenser en lien à ce qu’est le sujet, sur ce qu’est une tradition, à repenser comme cristallisation culturelle (...) et institutionnelle d’une voie d’accomplissement de l’humain, à investir et valider comme telle, hors système auto-référencié. L’article fait enfin retour sur ce qu’il en est du christianisme, dans sa consistance propre, en principe faite d’une suite d’acculturations au creux des sociétés et des cultures, et vivant d’instances diverses et irréductibles. L’article y reprend le motif de l’expérience dite religieuse et en rapport à ce qui peut être une transcendance, mais cristallisée en corps à corps avec le monde et ce qui s’en éprouve et s’en dit, une expérience alors féconde, mais ainsi seulement. (shrink)

C'est à emprunter un chemin d'écolier que nous invite ce livre. Un chemin qui part d'une rencontre, celle de la pensée de Heidegger, dans la khâgne de Jean Beaufret en 1946, où se joue l'intime d'une vocation philosophique. Un chemin jalonné d'anecdotes savoureuses, où l'on croise toutes les grandes figures de la pensée française de la seconde moitié du XXe siècle, de Gandillac à Boutang, de Foucault à Michel Henry, dialoguant avec Platon, Montaigne ou Bergson. Un chemin où l'âme d'un (...) vieux maître d'école se recueille pour mieux se livrer, et "conjuguer une fois encore la poussière et l'étoile."--Page 4 of cover. (shrink)